Scientist (LC-MS systems and proteomics workflows)

Job Title: Scientist

Location: South San Francisco, CA

Terms: Contract W2 Only

Contract: 12 months initially; potential for extension

Description:

Work Model: Primarily onsite/lab based. Expectation should be communicated as 5 days onsite, although occasional remote work may be possible when work is limited to data analysis.

Schedule: Standard business hours, roughly 8–5 or similar. No anticipated overtime or weekend work.

Role Overview:

This Scientist will support Discovery Proteomics and internal target-discovery efforts. The position is heavily laboratory-based and requires hands-on experience with mass spectrometry-based proteomics, including LC-MS workflows, sample preparation, and proteomics data analysis.

Work may include activities such as sample preparation, pull-down/enrichment-type workflows, PTM analysis, LC-MS operation/troubleshooting, and downstream proteomics data analysis.

Candidate Profile

Preferred Education/Experience:

PhD preferred; a fresh PhD is acceptable

Master’s degree may be considered with approximately 5+ years of relevant experience

Previous industry experience is not necessarily required if the candidate has strong, directly applicable academic/research experience

Core Requirements:

Hands-on LC-MS / mass spectrometry-based proteomics experience

Ability to independently operate, evaluate, and troubleshoot LC-MS systems/workflows

Experience with commonly used proteomics data-analysis software

Experience preparing samples for mass spectrometry analysis

Strong

We are seeking a Scientist-level contract worker with expertise in LC-MS–based proteomics. The Scientist will support early discovery programs and technology platforms through discovery and targeted proteomic analyses, including cell surface proteomics, proximity labeling, target validation, and mechanism-of-action studies. The role requires hands-on expertise in proteomic sample preparation, LC-MS operation, and quantitative proteomics data analysis.

Top 3 Must Have Skill Sets:

1. Independently operate, evaluate, and troubleshoot LC-MS systems and proteomics workflows.

2. Process and evaluate proteomics data using software such as Proteome Discoverer, Spectronaut, and DIA-NN.

3. Experience working with diverse biological samples, such as cell lines, tissues, biofluids, and/or FFPE samples for mass spec based proteomic analysis