Senior Director, PMO Strategic Portfolio Management & AI Innovation

At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we’re in. Are you?

About the Role:

Seeking a dynamic Senior Director to join our Program Management Operations (PMO) team. Reporting to the Executive Director, Portfolio Strategy & PMO, this role is critical in driving AI-enabled portfolio strategy initiatives, overseeing comprehensive portfolio reporting, and leading the planning and execution of strategic and operational initiatives across Insmed’s portfolio. This role offers an exciting opportunity to leverage cutting-edge AI technologies and data analytics to optimize portfolio decisions, transform reporting capabilities, and contribute to bringing innovative therapies to patients with serious diseases.

What You’ll Do:

In this role, you will design and execute strategic initiatives that optimize portfolio performance and resource allocation. Additionally, you will collaborate with cross-functional teams to integrate AI and machine learning capabilities into portfolio management and reporting processes

You will also have responsibility for:

Portfolio Reporting & Analytics:

• Design and implement AI-enabled reporting frameworks that automate data collection, analysis, and visualization
• Develop advanced analytics dashboards and predictive modeling tools for portfolio performance monitoring
• Leverage AI/ML technologies to identify portfolio-level risks, trends, opportunities, and strategic insights from reporting data
• Establish standardized reporting metrics, KPIs, and governance processes across the portfolio

Strategic Portfolio Management:

• Lead the development and implementation of AI-driven portfolio strategy frameworks and decision-making tools
• Support senior leadership in strategic planning and portfolio optimization decisions based on data-driven insights
• Provide strategic oversight and guidance on portfolio prioritization and resource allocation

AI Innovation & Process Excellence:

• Lead operational excellence initiatives across the PMO organization
• Identify opportunities for process improvement and automation using AI/ML technologies
• Develop and maintain portfolio analytics platforms that enable real-time decision-making

Cross-Functional Leadership:

• Manage complex, multi-functional strategic projects from conception to completion
• Coordinate activities across Business Development, Program Management, Commercial, Regulatory Affairs, Medical Affairs, Technical Operations, Clinical Development, and Finance

Who You Are:

You have an advanced degree in business, engineering, data science, life sciences, or related field, and a minimum 10-12 years of strategic planning, portfolio management, or management consulting experience, with at least 5 years in pharmaceutical/biotechnology industry

Additionally you have:

• Proven experience with AI/ML applications in business strategy, portfolio management, or reporting/analytics
• Strong understanding of drug development processes and pharmaceutical business modelsExpertise in data analytics, predictive modeling, business intelligence tools, and reporting platforms
• Experience with portfolio reporting, performance measurement, and executive-level communications
• Entrepreneurial self-starter with a proven track record of success in fast-paced environments
• Well-developed technical skills (Python/R, SQL, Tableau/PowerBI, Excel, PowerPoint, MS Teams/SharePoint)

Preferred Qualifications

• MBA or advanced degree in data science, AI/ML, or related technical field
• Experience in respiratory diseases, immunology & inflammation, neurology/neuroscience, and/or rare diseases
• Knowledge of AI/ML platforms and tools (TensorFlow, PyTorch, cloud-based ML services)
• Project Management Professional (PMP) or similar certification
• Experience with portfolio optimization and resource allocation methodologies
• Background in business …